The labeling says the reactions are not dose dependent. Any drug that interferes with DNA is dangerous. What if it also interferes with normal cells not only bacterial cells? Our science is not advanced enough to be sure it doesn't. What else could explain the multi systemic ADRs many people have? Collagen disruption is admitted to by the drug maker. Collagen is necessary for healthy tissue in your whole body. I hope doctors think twice, thrice, a hundred times, before ruining someone else's life with quinolones. Anyone who thinks doctor knows best has some growing up to do. Educate yourselves, and know that side effects are a lot more common than drug companies with their flawed testing will lead you to believe. The quinolones gave me permanent damage in much of my body and ruined my life. If I told you the real extent of it no one would believe me. Go read the many stories online. It could be you.