Research indicates a tremendous amount of multiple case reports of tendinitis (particularly Archilles tendinitis) and tendon rupture in patients receiving as little as ONE dose of fluoroquinolones, months and in some cases years after such therapy. Such tendinopathy can occur within a few days, weeks, or even months following a course of fluoroquinolone therapy. Tendon rupture can occur without a history of specific trauma. There are numerous theories as to how this occurs but the exact mechanics of such damage, twenty years later, still remains a mystery.