Levofloxacin

Levofloxacin (Levaquin)

Delayed Reaction from Levaquin

I took Levaquin in Feb. of 2008 and did not experience anything until April. It comes on quickly - pain in all joints, neuropathy, headaches plus a multitude of other problems. I understand it is a long and arduous road back. As for me - I would NEVER take any fluroquinolone again. The FDA has posted a "black box" warning on these medications. It has ruined my life.

— Ann

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Severe Toxicity of Floxin (and Levofloxacin)

Floxin has also a distinctive profile: many times floxin causes extremely delayed reactions at around the 18 months mark. Many persons take floxin without clear side effects, but after one and a half years, a full adverse reaction develops with plenty of floxing symptoms, in many cases of similar intensity to an intermediate reaction.

(Note that Levofloxacin is the same chemical as Ofloxacin, the atoms and chemical formula is exactly the same, only that Levofloxacin is shaped to be almost double in potency)

— T Boomer

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Safety results of Levofloxacin in pediatric patients

Of the 712 [pediatric] subjects evaluable for safety, 275 (52%) levofloxacin-treated subjects experienced one or more adverse event... Serious adverse events were reported in 33 (6%) levofloxacin-treated subjects...Two serious adverse events in levofloxacin-treated subjects resulted in fatal outcomes.

— John Bradley, M.D., Children’s Hospital and Health Center, San Diego, CA

A Study to Compare the Efficacy and Safety of Levofloxacin in the Treatment of Children With Community-Acquired Pneumonia in the Hospital or Outpatient Setting Source: http://download.veritasmedicine.com/PDF/CR002392_CSR.pdf

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I took Levaquin 2 months ago for a UTI. After the third dose, I went from a healthy 34 yr old to a 100 yr old woman. I had myalgia, extreme anxiety and panic, insomnia, tremors, neuropathy, tinnitus, blurred vision, and joint and tendon pain. Most of the symptoms have either diminished or gone away except for the joint and tendon pain, tinnitus, blurred vision, slight neuropathy, and some anxiety.

— Seena

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Multi-System Worsening Long Term damage

Fluoroquinolone antibiotics have damaged many people. I know of this severe damage on a personal level since I suffered such and adverse reaction to the fluoroquinolone antibiotic Levaquin myself 22 months ago. Since then I have had daily pain and disability of my nervous and musculoskeletal systems and for several months had endocrine and gastrointestinal problems as well.

— Todd Plumb, MD

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Since this experience I have had intermittant chest pain in one area only, EXTREME fatigue, and tinnitus. Most days are spent in a haze. I am so tired all of the time, but have difficulty falling asleep because of the ringing in my ears. I have not had one moment of quiet. There is no peace or quality left to my life.

— beltran9

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I took 10 days of levaquin. I have hearing loss, tinnitus,memory loss, and dI can hardly walk. This was from taking levaquin 10 months ago. I had mettalic taste, nightmares and psychotic episodes that have eased up over the last three months. The other problems will be with me for the rest of my life.

— helen950

http://www.medications.com/se/levaquin/tinnitus

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Just a note to let you know I am doing much better. It was scary for a couple of months after taking two weeks of Levaquin. I had sudden joint pain, extreme muscle weakness, extreme fatigue, rash, headache, mental confusion.

I was tested for Lupus, Lymes, Arthritis, MS, ALS, etc, etc. I kept telling the Doc's it was due to the Levaquin because my symptoms started while I was taking the Levaquin for an "infection." There never was any "infection."

— karenp

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Possibly higher rates of neurotoxicity with levofloxacin

"Thus, this trend may reflect... a previously unrecognized tendency toward greater neurotoxicity with levofloxacin."

— JS Cohen, MD

Cohen JS (December 2001). "Peripheral Neuropathy Associated with Fluoroquinolones" (PDF). Ann Pharmacother 35 (12): 1540–7. doi:10.1345/aph.1Z429. PMID 11793615. http://fqvictims.org/fqvictims/News/neuropathy/Neuropathy.pdf

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Phototoxicity of quinolones in animals

The phototoxic effects of quinolone antimicrobial agents on mouse auricular skin and retina were examined histologically. Sparfloxacin at 50 or 100 mg/kg, which alone causes no histologic change, was orally administered to albino Balb/c mice, which were irradiated with ultraviolet A for 4 hr immediately after administration. In the auricle, degeneration of basal epidermal cells was sporadically observed at 2 hr (during the irradiation). Foci of slight edema with degenerated fibroblasts were seen in the dermis at 4 hr.

— K Shimoda, M Yoshida, N Wagai, S Takayama, M Kato

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