Ciprofloxacin

Ciprofloxacin (Cipro)

Quinolone Induced Mitochondrial DNA Damage

The loss in mtDNA was associated with a delayed loss in mitochondrial function. Here, we report that the 4-quinolone drug ciprofloxacin is cytotoxic to a variety of cultured mammalian cell lines at concentrations that deplete cells of mtDNA. The IC50 values for ciprofloxacin varied from 40 to 80 micrograms/ml depending on the cell line tested. Cytotoxicity required continuous exposure of cells to drug for 2-4 days, which corresponded to approximately three or four cell doublings. Shorter times of drug exposure did not cause significant cytotoxicity.

— JW Lawrence, DC Claire, V Weissig, TC Rowe, Department of Pharmacology and Therapeutics, University of Florida College of Medicine

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Severe reaction in young and healthy athlete

On my 23rd birthday I started ciproI only took 3 doses of cipro in total before realizing what was happening… I went from being a very healthy 23 year old male who was athletic for over 10 years doing Karate, Yoga, Football, Judo and other sports, I eat an extremely healthy diet, no bad foods at all, and generally take care of myself in everyway possible, I have never drank alcohol and never smoked… I have all the blood tests and other tests to prove how healthy I was.

— Matthew

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Spontaneous Achilles tendon rupture

We report two cases of tendon rupture associated with ciprofloxacin. One patient had a complete rupture of an Achilles tendon 6 months after taking the medication. The other case involved a partial rupture of the subscapularis tendon. Both ruptures occurred with minimal mechanical stress on the tendons, suggesting that the fluoroquinolone increased the susceptibility to rupture...

— J. Michael Casparian, MD, Michael Luchi, MD, Department of Medicine, University of Kansas

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Ototoxicity of quinolones

Ciprofloxacin belongs to the Quinolone class of drugs, all of which can be quite ototoxic. Ciprofloxacin can cause severe hearing loss, loud tinnitus, ataxia, dizziness, nystagmus, vertigo and ear pain. Thus, it is a drug to be taken with caution. Since I’ve had a number of people tell me of their woes after taking Ciprofloxacin, the ototoxic side effects must be relatively common.

— Neil Bauman, Ph.D.

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Hearing damage from Cipro

"I only took Ciprofloxacin for three days which resulted in profound bilateral hearing loss, tinnitus and inner ear damage that affects my balance."

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Quinolone tendon rupture warning

Ciprofloxacin and other quinolones have been shown to cause arthropathy in immature animals of most species tested. Damage of weight bearing joints was observed in juvenile dogs and rats. In young beagles, 100 mg/kg ciprofloxacin, given daily for 4 weeks, caused degenerative articular changes of the knee joint.

— Schering-Plough Corporation

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Permanent respiratory problems

"I've had respiratory problems ever since [I took Cipro]"

— Rick Stonecypher

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"Think twice before taking a quinolone"

Cipro is the quintessential kind of drug that people take like candy because they think all drugs are safe. With so many horrible things going on in this world, some people want to believe that if they take this pill, it will protect them. But that's not how it works, and what people don't understand is that these drugs can cause illness... A lot of people get these drugs for the most minor infections, but there are a lot of people who should think twice before taking a quinolone for anything.

— Stephen Fried

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