Peripheral Nervous System Symptoms

Tendon problems are just the "tip of the iceberg"

The fact that Cipro and quinolones can cause permanent, untreatable tendon damage as highlighted by the need for a black box warning, that leaves patients with crippling untreatable pain, is only the tip of the iceberg when it comes to the other severe and permanently disabling adverse reactions that Cipro and other quinolones can inflict. The product information sheets provided by quinolone manufacturers also fail to indicate that some individuals will suffer from multiple adverse reactions that will become permanent and untreatable.

— DBCipro, White Plains, NY

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Delayed Reaction from Levaquin

I took Levaquin in Feb. of 2008 and did not experience anything until April. It comes on quickly - pain in all joints, neuropathy, headaches plus a multitude of other problems. I understand it is a long and arduous road back. As for me - I would NEVER take any fluroquinolone again. The FDA has posted a "black box" warning on these medications. It has ruined my life.

— Ann

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Extremely Delayed Reaction

I took floxin 12 years ago for three weeks for a virus that attacked my liver. For the last two months I've had neurologic symptoms, some fatigue, numbness in head, neck, arm, knee, tight muscles, spasms.

— javelina101

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I took Levaquin 2 months ago for a UTI. After the third dose, I went from a healthy 34 yr old to a 100 yr old woman. I had myalgia, extreme anxiety and panic, insomnia, tremors, neuropathy, tinnitus, blurred vision, and joint and tendon pain. Most of the symptoms have either diminished or gone away except for the joint and tendon pain, tinnitus, blurred vision, slight neuropathy, and some anxiety.

— Seena

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Every morning when I open my eyes, I awaken to this nightmare. There is a “sickness” that feels like my body has been poisoned. My hands and feet are swelled and sore…my entire body is stiff and painful…heart-palpitations, vibrations throughout my body…ringing in my ears…bleeding specks of sores on my skin…and a full, bloated feeling in my gut…I feel like I should be dead. It is only by the grace of God, and the love of my 2 children that I am able to pull myself up out of bed, and make it painfully down the stairs.

— Shelley

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Severe reaction in young and healthy athlete

On my 23rd birthday I started ciproI only took 3 doses of cipro in total before realizing what was happening… I went from being a very healthy 23 year old male who was athletic for over 10 years doing Karate, Yoga, Football, Judo and other sports, I eat an extremely healthy diet, no bad foods at all, and generally take care of myself in everyway possible, I have never drank alcohol and never smoked… I have all the blood tests and other tests to prove how healthy I was.

— Matthew

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Multi-System Worsening Long Term damage

Fluoroquinolone antibiotics have damaged many people. I know of this severe damage on a personal level since I suffered such and adverse reaction to the fluoroquinolone antibiotic Levaquin myself 22 months ago. Since then I have had daily pain and disability of my nervous and musculoskeletal systems and for several months had endocrine and gastrointestinal problems as well.

— Todd Plumb, MD

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Possibly higher rates of neurotoxicity with levofloxacin

"Thus, this trend may reflect... a previously unrecognized tendency toward greater neurotoxicity with levofloxacin."

— JS Cohen, MD

Cohen JS (December 2001). "Peripheral Neuropathy Associated with Fluoroquinolones" (PDF). Ann Pharmacother 35 (12): 1540–7. doi:10.1345/aph.1Z429. PMID 11793615. http://fqvictims.org/fqvictims/News/neuropathy/Neuropathy.pdf

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Acknowledgement of irreversible neuropathy

Peripheral Neuropathy: Levaquin [or any other quinolone] should be discontinued if the patient experiences symptoms of neuropathy including pain, burning, tingling, numbness, and/or weakness or other alterations of sensation including light touch, pain, tempeture, position sense, and vibratory sensation in order to prevent the development of an irreversible condition.

— Ortho McNeil

Package insert of Levaquin

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Long term multiple organ damage

In contrast, in recent years hundreds of reports involving fluoroquinolone-associated events involving the central nervous system (CNS), musculoskeletal system, and peripheral nervous system (PNS) have been posted on Internet Web sites by patients or concerned family members. Many of these events are described as severe and longlasting, causing substantial pain, impairment of functioning, and, in some cases, long-term disability.

— JS Cohen

Cohen JS (December 2001). "Peripheral Neuropathy Associated with Fluoroquinolones" (PDF). Ann Pharmacother 35 (12): 1540–7. doi:10.1345/aph.1Z429. PMID 11793615. http://fqvictims.org/fqvictims/News/neuropathy/Neuropathy.pdf

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