Posted Tue, 02/03/2009 - 21:51 by FQHelp
The loss in mtDNA was associated with a delayed loss in mitochondrial function. Here, we report that the 4-quinolone drug ciprofloxacin is cytotoxic to a variety of cultured mammalian cell lines at concentrations that deplete cells of mtDNA. The IC50 values for ciprofloxacin varied from 40 to 80 micrograms/ml depending on the cell line tested. Cytotoxicity required continuous exposure of cells to drug for 2-4 days, which corresponded to approximately three or four cell doublings. Shorter times of drug exposure did not cause significant cytotoxicity.
— JW Lawrence, DC Claire, V Weissig, TC Rowe, Department of Pharmacology and Therapeutics, University of Florida College of Medicine
Posted Tue, 02/03/2009 - 19:01 by FQHelp
I took Levaquin in Feb. of 2008 and did not experience anything until April. It comes on quickly - pain in all joints, neuropathy, headaches plus a multitude of other problems. I understand it is a long and arduous road back. As for me - I would NEVER take any fluroquinolone again. The FDA has posted a "black box" warning on these medications. It has ruined my life.
Posted Mon, 02/02/2009 - 21:51 by FQHelp
The Chicago teen-ager was also 16 when a physician told her mother to give her Levaquin, according to the girl's sister.
The sister, Mrs. Teri Noto of Roselle, Ill., said the teen-ager did not get through the full course of daily 500-milligram Levaquin pills.
"After five days, it was as if a bomb went off in her body," said the sister. "She collapsed at school and had to be half-carried out of the building."
Posted Mon, 02/02/2009 - 18:17 by FQHelp
I took floxin 12 years ago for three weeks for a virus that attacked my liver. For the last two months I've had neurologic symptoms, some fatigue, numbness in head, neck, arm, knee, tight muscles, spasms.
Posted Mon, 02/02/2009 - 18:05 by FQHelp
Floxin has also a distinctive profile: many times floxin causes extremely delayed reactions at around the 18 months mark. Many persons take floxin without clear side effects, but after one and a half years, a full adverse reaction develops with plenty of floxing symptoms, in many cases of similar intensity to an intermediate reaction.
(Note that Levofloxacin is the same chemical as Ofloxacin, the atoms and chemical formula is exactly the same, only that Levofloxacin is shaped to be almost double in potency)
Posted Thu, 01/22/2009 - 21:23 by FQHelp
On my 23rd birthday I started ciproI only took 3 doses of cipro in total before realizing what was happening… I went from being a very healthy 23 year old male who was athletic for over 10 years doing Karate, Yoga, Football, Judo and other sports, I eat an extremely healthy diet, no bad foods at all, and generally take care of myself in everyway possible, I have never drank alcohol and never smoked… I have all the blood tests and other tests to prove how healthy I was.
Posted Thu, 01/22/2009 - 21:19 by FQHelp
Fluoroquinolone antibiotics have damaged many people. I know of this severe damage on a personal level since I suffered such and adverse reaction to the fluoroquinolone antibiotic Levaquin myself 22 months ago. Since then I have had daily pain and disability of my nervous and musculoskeletal systems and for several months had endocrine and gastrointestinal problems as well.
Posted Thu, 01/22/2009 - 20:18 by FQHelp
We report two cases of tendon rupture associated with ciprofloxacin. One patient had a complete rupture of an Achilles tendon 6 months after taking the medication. The other case involved a partial rupture of the subscapularis tendon. Both ruptures occurred with minimal mechanical stress on the tendons, suggesting that the fluoroquinolone increased the susceptibility to rupture...
— J. Michael Casparian, MD, Michael Luchi, MD, Department of Medicine, University of Kansas
Posted Thu, 01/22/2009 - 20:12 by FQHelp
One day after juvenile rats were given a single dose of ofloxacin and pefloxacin, their Achilles tendons showed alterations of the collagen, edema, and an inflammatory infiltrate...
— J. Michael Casparian, MD, Michael Luchi, MD, Department of Medicine, University of Kansas
Posted Wed, 01/21/2009 - 21:38 by FQHelp
Research indicates a tremendous amount of multiple case reports of tendinitis (particularly Archilles tendinitis) and tendon rupture in patients receiving as little as ONE dose of fluoroquinolones, months and in some cases years after such therapy. Such tendinopathy can occur within a few days, weeks, or even months following a course of fluoroquinolone therapy. Tendon rupture can occur without a history of specific trauma. There are numerous theories as to how this occurs but the exact mechanics of such damage, twenty years later, still remains a mystery.
— The Fluoroquinolone Toxicity Research Foundation
