Posted Fri, 02/06/2009 - 15:36 by FQHelp
Quinolone usage in children has been limited following the observation of arthrotoxicity in juvenile animals... The arthropathy evolves within days to weeks of drug administration... it is hypothesized that the effect of quinolones in some animal species may reflect inhibition of mitochondrial DNA replication in immature chondrocytes
— Allan R. Ronald, Don E. Low
Fluoroquinolone Antibiotics, Birkhäuser, 2003, ISBN 3764365919, 9783764365912
Posted Tue, 02/03/2009 - 22:01 by FQHelp
Incorporation of labeled deoxynucleoside triphosphates into mtDNA by isolated rat liver mitochondria has been shown previously to reflect DNA replication. We have used this system to seek evidence for a mtDNA gyrase. Coumermycin, novobiocin, nalidixic acid, and oxolinic acid are known to be inhibitors of Escherichia coli gyrase, to inhibit E. coli DNA replication, to abolish colicin E1 replication, and to depress the supercoiling of phage lambda DNA, the last two via inhibition of the DNA gyrase.
— Frank J. Castora, Melvin V. Simpson, Department of Biochemistry, State University
of New York,
Posted Tue, 02/03/2009 - 21:51 by FQHelp
The loss in mtDNA was associated with a delayed loss in mitochondrial function. Here, we report that the 4-quinolone drug ciprofloxacin is cytotoxic to a variety of cultured mammalian cell lines at concentrations that deplete cells of mtDNA. The IC50 values for ciprofloxacin varied from 40 to 80 micrograms/ml depending on the cell line tested. Cytotoxicity required continuous exposure of cells to drug for 2-4 days, which corresponded to approximately three or four cell doublings. Shorter times of drug exposure did not cause significant cytotoxicity.
— JW Lawrence, DC Claire, V Weissig, TC Rowe, Department of Pharmacology and Therapeutics, University of Florida College of Medicine
Posted Tue, 02/03/2009 - 19:17 by FQHelp
The fact that Cipro and quinolones can cause permanent, untreatable tendon damage as highlighted by the need for a black box warning, that leaves patients with crippling untreatable pain, is only the tip of the iceberg when it comes to the other severe and permanently disabling adverse reactions that Cipro and other quinolones can inflict. The product information sheets provided by quinolone manufacturers also fail to indicate that some individuals will suffer from multiple adverse reactions that will become permanent and untreatable.
— DBCipro, White Plains, NY
Posted Mon, 02/02/2009 - 21:51 by FQHelp
The Chicago teen-ager was also 16 when a physician told her mother to give her Levaquin, according to the girl's sister.
The sister, Mrs. Teri Noto of Roselle, Ill., said the teen-ager did not get through the full course of daily 500-milligram Levaquin pills.
"After five days, it was as if a bomb went off in her body," said the sister. "She collapsed at school and had to be half-carried out of the building."
Posted Mon, 02/02/2009 - 18:05 by FQHelp
Floxin has also a distinctive profile: many times floxin causes extremely delayed reactions at around the 18 months mark. Many persons take floxin without clear side effects, but after one and a half years, a full adverse reaction develops with plenty of floxing symptoms, in many cases of similar intensity to an intermediate reaction.
(Note that Levofloxacin is the same chemical as Ofloxacin, the atoms and chemical formula is exactly the same, only that Levofloxacin is shaped to be almost double in potency)
Posted Mon, 01/26/2009 - 11:24 by FQHelp
Of the 712 [pediatric] subjects evaluable for safety, 275 (52%) levofloxacin-treated subjects experienced one or more adverse event... Serious adverse events were reported in 33 (6%) levofloxacin-treated subjects...Two serious adverse events in levofloxacin-treated subjects resulted in fatal outcomes.
— John Bradley, M.D., Children’s Hospital and Health Center, San Diego, CA
Posted Sun, 01/25/2009 - 20:48 by FQHelp
The risk-benefit assessment indicates that levofloxacin is only appropriate in pediatric patients for treatment of inhalational anthrax (post-exposure).
Posted Sat, 01/24/2009 - 22:11 by FQHelp
We observed ultrastructural changes in rat tendons several months after a single oral dose of a fluoroquinolone. I have no doubt what we found in rats corresponds to the clinical symptoms observed in patients during [fluoroquinolone] treatment.
Posted Sat, 01/24/2009 - 22:08 by FQHelp
"Doctors fail to realise that these drugs have a proven history of severe toxicity. They are not and cannot be considered first line agents, but drugs of absolute last resort."
