Quotes from doctors and other professional sources
Posted Tue, 02/03/2009 - 21:51 by FQHelp
The loss in mtDNA was associated with a delayed loss in mitochondrial function. Here, we report that the 4-quinolone drug ciprofloxacin is cytotoxic to a variety of cultured mammalian cell lines at concentrations that deplete cells of mtDNA. The IC50 values for ciprofloxacin varied from 40 to 80 micrograms/ml depending on the cell line tested. Cytotoxicity required continuous exposure of cells to drug for 2-4 days, which corresponded to approximately three or four cell doublings. Shorter times of drug exposure did not cause significant cytotoxicity.
— JW Lawrence, DC Claire, V Weissig, TC Rowe, Department of Pharmacology and Therapeutics, University of Florida College of Medicine
Posted Mon, 01/26/2009 - 11:24 by FQHelp
Of the 712 [pediatric] subjects evaluable for safety, 275 (52%) levofloxacin-treated subjects experienced one or more adverse event... Serious adverse events were reported in 33 (6%) levofloxacin-treated subjects...Two serious adverse events in levofloxacin-treated subjects resulted in fatal outcomes.
— John Bradley, M.D., Children’s Hospital and Health Center, San Diego, CA
Posted Sun, 01/25/2009 - 20:48 by FQHelp
The risk-benefit assessment indicates that levofloxacin is only appropriate in pediatric patients for treatment of inhalational anthrax (post-exposure).
Posted Sat, 01/24/2009 - 22:11 by FQHelp
We observed ultrastructural changes in rat tendons several months after a single oral dose of a fluoroquinolone. I have no doubt what we found in rats corresponds to the clinical symptoms observed in patients during [fluoroquinolone] treatment.
Posted Thu, 01/22/2009 - 21:19 by FQHelp
Fluoroquinolone antibiotics have damaged many people. I know of this severe damage on a personal level since I suffered such and adverse reaction to the fluoroquinolone antibiotic Levaquin myself 22 months ago. Since then I have had daily pain and disability of my nervous and musculoskeletal systems and for several months had endocrine and gastrointestinal problems as well.
Posted Thu, 01/22/2009 - 20:43 by FQHelp
"Thus, this trend may reflect... a previously unrecognized tendency toward greater neurotoxicity with levofloxacin."
Posted Thu, 01/22/2009 - 20:23 by FQHelp
The newest fluoroquinolones may benefit some patients, but their ease of use may promote indiscriminate use. The risk/benefit ratio of the fluoroquinolones should be carefully considered, and these drugs should be prescribed cautiously, since better-tolerated, less expensive drugs can usually be prescribed instead.
Posted Thu, 01/22/2009 - 20:18 by FQHelp
We report two cases of tendon rupture associated with ciprofloxacin. One patient had a complete rupture of an Achilles tendon 6 months after taking the medication. The other case involved a partial rupture of the subscapularis tendon. Both ruptures occurred with minimal mechanical stress on the tendons, suggesting that the fluoroquinolone increased the susceptibility to rupture...
— J. Michael Casparian, MD, Michael Luchi, MD, Department of Medicine, University of Kansas
Posted Thu, 01/22/2009 - 20:12 by FQHelp
One day after juvenile rats were given a single dose of ofloxacin and pefloxacin, their Achilles tendons showed alterations of the collagen, edema, and an inflammatory infiltrate...
— J. Michael Casparian, MD, Michael Luchi, MD, Department of Medicine, University of Kansas
Posted Thu, 01/22/2009 - 19:20 by FQHelp
Ciprofloxacin belongs to the Quinolone class of drugs, all of which can be quite ototoxic. Ciprofloxacin can cause severe hearing loss, loud tinnitus, ataxia, dizziness, nystagmus, vertigo and ear pain. Thus, it is a drug to be taken with caution. Since I’ve had a number of people tell me of their woes after taking Ciprofloxacin, the ototoxic side effects must be relatively common.
