Pediatric Use

Use of quinolones in children and adolescents under the age of 18.

Inhibition of Replication of Chrondrocytes

Posted Fri, 02/06/2009 - 15:36 by FQHelp

Quinolone usage in children has been limited following the observation of arthrotoxicity in juvenile animals... The arthropathy evolves within days to weeks of drug administration... it is hypothesized that the effect of quinolones in some animal species may reflect inhibition of mitochondrial DNA replication in immature chondrocytes

— Allan R. Ronald, Don E. Low

Fluoroquinolone Antibiotics, Birkhäuser, 2003, ISBN 3764365919, 9783764365912

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Serious Reaction from Levaquin in Adolescent

Posted Mon, 02/02/2009 - 21:51 by FQHelp

The Chicago teen-ager was also 16 when a physician told her mother to give her Levaquin, according to the girl's sister.

The sister, Mrs. Teri Noto of Roselle, Ill., said the teen-ager did not get through the full course of daily 500-milligram Levaquin pills.

"After five days, it was as if a bomb went off in her body," said the sister. "She collapsed at school and had to be half-carried out of the building."

— YourLawyer.com

http://www.yourlawyer.com/articles/read/10462

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Safety results of Levofloxacin in pediatric patients

Posted Mon, 01/26/2009 - 11:24 by FQHelp

Of the 712 [pediatric] subjects evaluable for safety, 275 (52%) levofloxacin-treated subjects experienced one or more adverse event... Serious adverse events were reported in 33 (6%) levofloxacin-treated subjects...Two serious adverse events in levofloxacin-treated subjects resulted in fatal outcomes.

— John Bradley, M.D., Children’s Hospital and Health Center, San Diego, CA

A Study to Compare the Efficacy and Safety of Levofloxacin in the Treatment of Children With Community-Acquired Pneumonia in the Hospital or Outpatient Setting Source: http://download.veritasmedicine.com/PDF/CR002392_CSR.pdf

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Only appropriate in children for anthrax

Posted Sun, 01/25/2009 - 20:48 by FQHelp

The risk-benefit assessment indicates that levofloxacin is only appropriate in pediatric patients for treatment of inhalational anthrax (post-exposure).

— Ortho McNeil

http://www.fqresearch.org/pdf_files/Levaquin_11_2008_ortho_mcneil_dear_dr_letter.pdf and http://www.tmlt.org/risk/riskalert/levaquin.pdf

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Permanent tendon damage from low dosages

Posted Thu, 01/22/2009 - 20:12 by FQHelp

One day after juvenile rats were given a single dose of ofloxacin and pefloxacin, their Achilles tendons showed alterations of the collagen, edema, and an inflammatory infiltrate...

— J. Michael Casparian, MD, Michael Luchi, MD, Department of Medicine, University of Kansas

http://www.medscape.com/viewarticle/410546_print

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Quinolone tendon rupture warning

Posted Wed, 01/21/2009 - 21:18 by FQHelp

Ciprofloxacin and other quinolones have been shown to cause arthropathy in immature animals of most species tested. Damage of weight bearing joints was observed in juvenile dogs and rats. In young beagles, 100 mg/kg ciprofloxacin, given daily for 4 weeks, caused degenerative articular changes of the knee joint.

— Schering-Plough Corporation

http://www.drugs.com/pro/cipro-iv.html

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